Experimental Characterization and Mathematical Modeling of P2X7 Receptor Channel Gating
نویسندگان
چکیده
منابع مشابه
Experimental characterization and mathematical modeling of P2X7 receptor channel gating.
The P2X7 receptor is a trimeric channel with three binding sites for ATP, but how the occupancy of these sites affects gating is still not understood. Here we show that naive receptors activated and deactivated monophasically at low and biphasically at higher agonist concentrations. Both phases of response were abolished by application of Az10606120, a P2X7R-specific antagonist. The slow second...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2010
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.2390-10.2010